ALPHA-CGRP (8-37) (RAT)
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-
CAS: 129121-73-9
Molecular Formula: C138H224N42O41
ALPHA-CGRP (8-37) (RAT) - Names and Identifiers
ALPHA-CGRP (8-37) (RAT) - Physico-chemical Properties
| Molecular Formula | C138H224N42O41 |
| Molar Mass | 3127.51 |
| Storage Condition | -20°C |
| In vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| In vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels. |
ALPHA-CGRP (8-37) (RAT) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.32 ml | 1.599 ml | 3.197 ml |
| 5 mM | 0.064 ml | 0.32 ml | 0.639 ml |
| 10 mM | 0.032 ml | 0.16 ml | 0.32 ml |
| 5 mM | 0.006 ml | 0.032 ml | 0.064 ml |
Last Update：2024-01-02 23:10:35
ALPHA-CGRP (8-37) (RAT) - Reference Information
| biological activity | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selected CGRP receptor antagonist. |
| target | CGRP receptor |
| in vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| in vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a pose-dependent manner. The 50 nM pose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basic levels. |
Last Update：2024-04-09 21:54:55
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View History
ALPHA-CGRP (8-37) (RAT)
1-[4-[[2-(1-甲基乙氧基)乙氧基]甲基]-苯氧基]-3-[(1-甲基乙基)氨基]-2-丙醇富马酸盐
嘌呤核苷磷酸化酶抑制剂(PNP抑制剂)(FORODESINE盐酸盐)
LABOTEST-BB LT01595956
potassium tri-sec-butylhydroborate
BETAMETHASONE 17-ALPHA,21-DIPROPIONATE
RIWLPSIAFBLILR-CPCUXHMXSA-N
甲磺酸酐, 2M 在二氯甲烷中
(2S)-2-氨基-N-[(1S)-3-氨基-1-(氨基羰基)丙基]-5-[[亚氨基(硝基氨基)甲基]氨基]戊酰胺二(三氟乙酸盐)
CZC-25146 (hydrochloride)
1-[4-[[2-(1-甲基乙氧基)乙氧基]甲基]-苯氧基]-3-[(1-甲基乙基)氨基]-2-丙醇富马酸盐
嘌呤核苷磷酸化酶抑制剂(PNP抑制剂)(FORODESINE盐酸盐)
LABOTEST-BB LT01595956
potassium tri-sec-butylhydroborate
BETAMETHASONE 17-ALPHA,21-DIPROPIONATE
RIWLPSIAFBLILR-CPCUXHMXSA-N
甲磺酸酐, 2M 在二氯甲烷中
(2S)-2-氨基-N-[(1S)-3-氨基-1-(氨基羰基)丙基]-5-[[亚氨基(硝基氨基)甲基]氨基]戊酰胺二(三氟乙酸盐)
CZC-25146 (hydrochloride)